Review Article
DNA Methylation in Atherosclerosis: A New Perspective
Table 1
Compounds from Chinese herbal medicines regulate DNA methylation in AS.
| Herbs | Active compound | Target genes | Category of methylation effect | Mechanism of regulating DNA methylation | Models | Diseases | In vitro/in vivo | Reference |
| Curcuma longa | Curcumin | RNA18S5 and SIRT7 | Hypermethylation | DNMT2↑ | Vascular smooth muscle cells | AS | In vitro | [45] |
| Gardenia species | Geniposide | Akt2, Arrb, Tnf., and so on | Hypermethylation and hypomethylation | | Ox-LDL-induced foam cells | AS | In vitro | [47] |
| Polygonum cuspidatum | Resveratrol | PTEN | Hypomethylation | DNMT1↓ | Vascular smooth muscle cells | AS | In vitro | [49] |
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Sirtuin-7 (SIRT7), phosphatase and tensin homolog on chromosome 10 (PTEN), protein kinase Akt-2 (Akt2), arrestin beta 1 (Arrb), and tumor necrosis factor (Tnf).
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