Uncovering the Mechanism of Curcuma in the Treatment of Ulcerative Colitis Based on Network Pharmacology, Molecular Docking Technology, and Experiment Verification

Figure 1

The workflow of the study. Chemical constituents of curcuma were collected from TCMSP, SGST, CNKI, and PubMed based on druglikeness and oral bioavailability. The active compounds were collected further and imported into Swiss Target Prediction to get protein targets of curcuma. Then, we obtained UC-related genes from GeneCards and DrugBank, and coincident genes from curcuma and UC were collected for molecular docking to filter the proteins binding with compounds stronger than 5-ASA. PPI network was carried out by using the STRING database. GO and KEGG pathway analyses were performed by Metascape, and compound-target-pathway network was executed by Cytoscape. Further experimental verification and pathway analysis were carried out to interpret the mechanism.