Research Article

Use of Network Pharmacology to Explore the Mechanism of Gegen (Puerariae lobatae Radix) in the Treatment of Type 2 Diabetes Mellitus Associated with Hyperlipidemia

Table 2

Common targets of Gegen, type 2 diabetes mellitus, and hyperlipidemia.

Entrez IDGene symbolUniprot IDProtein name

154ADRB2P07550Beta-2 adrenergic receptor
185AGTR1P30556Type-1 angiotensin II receptor
231AKR1B1P15121Aldo-keto reductase family 1 member B1
217ALDH2P05091Aldehyde dehydrogenase, mitochondrial
240ALOX5P09917Polyunsaturated fatty acid 5-lipoxygenase
268AMHP03971Muellerian-inhibiting factor
335APOA1P02647Apolipoprotein A-I
338APOBP04114Apolipoprotein B-100
673BRAFP15056Serine/threonine-protein kinase B-raf
847CATP04040Catalase
6347CCL2P13500C-C motif chemokine 2
1019CDK4P11802Cyclin-dependent kinase 4
1066CES1P23141Liver carboxylesterase 1
1588CYP19A1P11511Aromatase
1591CYP24A1Q079731,25-Dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial
1564CYP2D7A0A087X1C5Putative cytochrome P450 2D7
1576CYP3A4P08684Cytochrome P450 3A4
1798DPAGT1Q9H3H5UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase
1956EGFRP00533Epidermal growth factor receptor
2099ESR1P03372Estrogen receptor
2100ESR2Q92731Estrogen receptor beta
2155F7P08709Coagulation factor VII
2169FABP2P12104Fatty acid-binding protein, intestinal
2167FABP4P15090Fatty acid-binding protein, adipocyte
2539G6PDP11413Glucose-6-phosphate 1-dehydrogenase
2641GCGP01275Pro-glucagon
2645GCKP35557Hexokinase-4
2690GHRP10912Growth hormone receptor
3156HMGCRP040353-Hydroxy-3-methylglutaryl-Coenzyme A reductase
3162HMOX1P09601Heme oxygenase 1
3290HSD11B1P28845Corticosteroid 11-beta-dehydrogenase isozyme 1
3553IL1BP01584Interleukin-1 beta
3569IL6P05231Interleukin-6
3630INSP01308Insulin
3643INSRP06213Insulin receptor
3718JAK3P52333Tyrosine-protein kinase JAK3
3949LDLRP01130Low-density lipoprotein receptor
5595MAPK3P27361Mitogen-activated protein kinase 3
8972MGAMO43451Maltase-glucoamylase, intestinal
4318MMP9P14780Matrix metalloproteinase-9
4552MTRRQ9UBK8Methionine synthase reductase
4846NOS3P29474Nitric oxide synthase, endothelial
7376NR1H2P55055Oxysterols receptor LXR-beta
10062NR1H3Q13133Oxysterols receptor LXR-alpha
9971NR1H4Q96RI1Bile acid receptor
2908NR3C1P04150Glucocorticoid receptor
5327PLATP00750Tissue-type plasminogen activator
5444PON1P27169Serum paraoxonase/arylesterase 1
5465PPARAQ07869Peroxisome proliferator-activated receptor alpha
5467PPARDQ03181Peroxisome proliferator-activated receptor delta
5468PPARGP37231Peroxisome proliferator-activated receptor gamma
5617PRLP01236Prolactin
5747PTK2Q05397Focal adhesion kinase 1
6256RXRAP19793Retinoic acid receptor RXR-alpha
6401SELEP16581E-selectin
6403SELPP16109P-selectin
6462SHBGP04278Sex hormone-binding globulin
6647SOD1P00441Superoxide dismutase [Cu-Zn]
6652SORDQ00796Sorbitol dehydrogenase
6721SREBF2Q12772Sterol regulatory element-binding protein 2
7077TIMP2P16035Metalloproteinase inhibitor 2
7099TLR4O00206Toll-like receptor 4
7124TNFP01375Tumor necrosis factor
7412VCAM1P19320Vascular cell adhesion protein 1
7422VEGFAP15692Vascular endothelial growth factor A