Acupuncture as Adjuvant Therapy for Treating Stable Angina Pectoris with Moderate Coronary Artery Lesions and the Mechanism of Heart-Brain Interactions: A Randomized Controlled Trial Protocol

Table 1

Study schedule.

Period	Baseline	Screening	Treatment	Follow-up
Week	−2	0	2	4
Informed consent	x
Inclusion/exclusion criteria		x
Medical history	x
Concomitant disease/medication	x	x	x	x
Physical examination	x	x	x
CCS angina class		x	x
SAQ scoring		x	x
HRV		x	x
SAS and SDS scoring		x	x
MRI scan		x	x
Blood glucose, pressure, and lipid tests		x
Blood, liver, and renal function tests		x
Adverse events			x
Patient compliance		x	x	x
Reasons of withdrawals			x	x
Safety evaluation		x	x	x

CCS, Canadian Cardiovascular Society; HRV, heart rate variability; SAQ, Seattle Angina Questionnaire; SAS, self-rating anxiety scale; SDS, self-rating depression scale.