Total Flavonoids of Rhizoma Drynariae Restore the MMP/TIMP Balance in Models of Osteoarthritis by Inhibiting the Activation of the NF- and PI3K/AKT Pathways

Figure 4

Effects of total flavonoids of Rhizoma Drynariae (TFRD) on MMP-1, MMP-3, MMP-13, and TIMP-4 mRNA expression in articular cartilage in the different groups. Group a, blank control group; Group b, OA model group (established with the Hulth method); Group c, TFRD-treated group (treated with TFRD after model induction with the Hulth method). The data are derived from six independent experiments and expressed as the mean ± standard deviation ( < 0.05 compared with Group a; ^# < 0.05 compared with Group b).

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