Research Article
Transcriptome Profiling of Human Follicle Dermal Papilla Cells in response to Porphyra-334 Treatment by RNA-Seq
Table 1
Measurement of improvement of periorbital wrinkling according to six parameters.
| Evaluation parameter | Time point | Test group | Control group | Test/Control | Mean ± SD | Change (%) | value † | Mean ± SD | Change (%) | value † | value |
| R1 | Baseline | 0.223 ± 0.050 | — | — | 0.214 ± 0.051 | — | — | — | 6 W | 0.211 ± 0.052 | −5 | 0.1 | 0.205 ± 0.054 | −3 | ≤0.001∗ | 0.7 | 12 W | 0.198 ± 0.040 | −10 | 0.2 | 0.209 ± 0.048 | −1 | 0.5 | 0.047# |
| R2 | Baseline | 0.138 ± 0.033 | — | — | 0.131 ± 0.027 | — | — | — | 6 W | 0.130 ± 0.030 | −6 | 0.007∗ | 0.136 ± 0.037 | 3.3 | 0.3 | 0.040# | 12 W | 0.120 ± 0.024 | −12 | ≤0.001∗ | 0.137 ± .035 | 4.7 | 0.2 | ≤0.001# |
| R3 | Baseline | 0.100 ± 0.025 | — | — | 0.097 ± 0.020 | — | — | — | 6 W | 0.093 ± 0.025 | −7 | ≤0.001∗ | 0.100 ± 0.025 | 2.9 | 0.2 | 0.003# | 12 W | 0.087 ± 0.021 | −13 | ≤0.001∗ | 0.098 ± 0.022 | 1.1 | 0.7 | ≤0.001# |
| R4 | Baseline | 0.125 ± 0.034 | — | — | 0.120 ± 0.035 | — | — | — | 6 W | 0.117 ± 0.034 | −5 | 0.1 | 0.111 ± 0.037 | −7 | 0.1 | 0.8 | 12 W | 0.112 ± 0.026 | −8 | 0.006∗ | 0.115 ± 0.035 | −3 | 0.3 | 0.4 |
| R5 | Baseline | 0.042 ± 0.014 | — | — | 0.039 ± 0.012 | — | — | — | 6 W | 0.039 ± 0.014 | −7 | 0.1 | 0.036 ± 0.014 | −7 | 0.1 | 1 | 12 W | 0.037 ± 0.013 | −11 | 0.008† | 0.037 ± 0.010 | −1 | 0.3 | 0.4 |
| Visual assessment | Baseline | 4.409 ± 1.141 | — | — | 4.318 ± 1.171 | — | — | — | 6 W | 4.182 ± 1.532 | −8 | 0.1 | 4.500 ± 1.439 | 3.2 | 0.042∗ | 0.007‡ | 12 W | 4.000 ± 1.345 | −11 | 0.003† | 4.455 ± 1.371 | 2.5 | 0.1 | ≤0.001‡ |
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