Transcriptome Profiling of Human Follicle Dermal Papilla Cells in response to Porphyra-334 Treatment by RNA-Seq

Table 1

Measurement of improvement of periorbital wrinkling according to six parameters.

Evaluation parameter	Time point	Test group			Control group			Test/Control
		Mean ± SD	Change (%)	value †	Mean ± SD	Change (%)	value †	value
R1	Baseline	0.223 ± 0.050	—	—	0.214 ± 0.051	—	—	—
	6 W	0.211 ± 0.052	−5	0.1	0.205 ± 0.054	−3	≤0.001^∗	0.7
	12 W	0.198 ± 0.040	−10	0.2	0.209 ± 0.048	−1	0.5	0.047^#
R2	Baseline	0.138 ± 0.033	—	—	0.131 ± 0.027	—	—	—
	6 W	0.130 ± 0.030	−6	0.007^∗	0.136 ± 0.037	3.3	0.3	0.040^#
	12 W	0.120 ± 0.024	−12	≤0.001^∗	0.137 ± .035	4.7	0.2	≤0.001^#
R3	Baseline	0.100 ± 0.025	—	—	0.097 ± 0.020	—	—	—
	6 W	0.093 ± 0.025	−7	≤0.001^∗	0.100 ± 0.025	2.9	0.2	0.003^#
	12 W	0.087 ± 0.021	−13	≤0.001^∗	0.098 ± 0.022	1.1	0.7	≤0.001^#
R4	Baseline	0.125 ± 0.034	—	—	0.120 ± 0.035	—	—	—
	6 W	0.117 ± 0.034	−5	0.1	0.111 ± 0.037	−7	0.1	0.8
	12 W	0.112 ± 0.026	−8	0.006^∗	0.115 ± 0.035	−3	0.3	0.4
R5	Baseline	0.042 ± 0.014	—	—	0.039 ± 0.012	—	—	—
	6 W	0.039 ± 0.014	−7	0.1	0.036 ± 0.014	−7	0.1	1
	12 W	0.037 ± 0.013	−11	0.008^†	0.037 ± 0.010	−1	0.3	0.4
Visual assessment	Baseline	4.409 ± 1.141	—	—	4.318 ± 1.171	—	—	—
	6 W	4.182 ± 1.532	−8	0.1	4.500 ± 1.439	3.2	0.042^∗	0.007^‡
	12 W	4.000 ± 1.345	−11	0.003^†	4.455 ± 1.371	2.5	0.1	≤0.001^‡