Antihypernociceptive and Neuroprotective Effects of the Aqueous and Methanol Stem-Bark Extracts of Nauclea pobeguinii (Rubiaceae) on STZ-Induced Diabetic Neuropathic Pain

Figure 6

Effects of the aqueous and methanol extracts of N. pobeguinii on the levels of TNF-α (a), IL-1β (b), and IL-6 (c) in the sciatic nerves of diabetic mice. Data are expressed as the mean ± SEM of six animals per experimental group, compared by one-way analysis of variance followed by Tukey test; ^α <0.05, ^β <0.01, and ^λ <0.001 mean significantly different from the normal control group (no diabetic); and ^a <0.05, ^b <0.01, and ^c <0.001 mean significantly different from the diabetic control group. NC: normal control, DC: diabetic control, PGB30: mice that received 30 mg/kg/day pregabalin, AE150: mice that received 150 mg/kg/day of aqueous extract, AE300: mice that received 300 mg/kg/day of aqueous extract, ME150: mice that received 150 mg/kg/day of methanol extract, ME300: mice that received 300 mg/kg/day methanol extract, TNF: tumour necrosis factor, IL: interleukin.

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