Antihypernociceptive and Neuroprotective Effects of the Aqueous and Methanol Stem-Bark Extracts of Nauclea pobeguinii (Rubiaceae) on STZ-Induced Diabetic Neuropathic Pain

Figure 7

Effects of the aqueous and methanol extracts of N. pobeguinii on the levels of IGF (a) and NGF (b) in the sciatic nerves of diabetic mice. Data are expressed as the mean ± SEM of six animals per experimental group, compared by one-way analysis of variance followed by Tukey test; ^α <0.05, ^β <0.01, and ^λ <0.001 mean significantly different from the normal control group (nondiabetic); and ^b <0.01 and ^c <0.001 mean significantly different from the diabetic control group. NC: normal control, DC: diabetic control, PGB30: mice that received 30 mg/kg/day pregabalin, AE150: mice that received 150 mg/kg/day of aqueous extract, AE300: mice that received 300 mg/kg/day of aqueous extract, ME150: mice that received 150 mg/kg/day of methanol extract, ME300: mice that received 300 mg/kg/day methanol extract, IGF: insulin-like growth factor, NGF: nerve growth factor.

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