Antihypernociceptive and Neuroprotective Effects of the Aqueous and Methanol Stem-Bark Extracts of Nauclea pobeguinii (Rubiaceae) on STZ-Induced Diabetic Neuropathic Pain

Figure 8

Effects of the aqueous and methanol extracts of N. pobeguinii on the absolute time spent in the open arms (a) and closed arms (b) during 6 min of exposure to the elevated plus maze. Data are expressed as the mean ± SEM of six animals per experimental group, compared by two-way analysis of variance followed by Bonferroni’s test; ^λ <0.001 means significantly different from the normal control group (nondiabetic); and ^a <0.05, ^b <0:01, and ^c <0.001 mean significantly different from the diabetic control group; s: seconds.

(a)

(b)