Antihypernociceptive and Neuroprotective Effects of the Aqueous and Methanol Stem-Bark Extracts of Nauclea pobeguinii (Rubiaceae) on STZ-Induced Diabetic Neuropathic Pain
Table 1
Effects of the aqueous and methanol extracts of the N. pobeguinii on blood glucose level during 6 weeks after injection of streptozotocin in mice.
Treatment
Dose (mg/kg)
Period (week)
0
1
2
3
4
5
6
Normal control
—
106.67 ± 3.24
104.27 ± 2.18
109.07 ± 5.05
107.67 ± 3.62
104.67 ± 3.93
105.57 ± 2.99
106.40 ± 4.01
Diabetic control
—
104.06 ± 2.82
380.20 ± 8.50λ
440.03 ± 18.27λ
446.50 ± 17.88λ
445.03 ± 20.59λ
448.23 ± 18.13λ
456.50 ± 14.27λ
Pregabalin
30
109.67 ± 4.91
381.00 ± 8.65λ
434.50 ± 24.89λ
358.33 ± 13.04λc
354.33 ± 9.28λc
357.83 ± 13.19λc
352.13 ± 11.73λc
Aqueous extract
150
107.67 ± 0.95
376.00 ± 16.17λ
438.50 ± 16.55λ
258.31 ± 16.70λc
168.00 ± 8.75c
161.67 ± 5.25c
136.67 ± 6.07c
300
104.83 ± 1.49
366.67 ± 10.18λ
454.34 ± 18.21λ
224.88 ± 6.88λc
133.33 ± 5.50c
124.50 ± 4.28c
117.50 ± 5.06c
Methanol extract
150
105.33 ± 1.61
396.00 ± 11.55λ
448.04 ± 12.59λ
285.17 ± 4.07λc
190.02 ± 19.18c
176.83 ± 11.03c
140.17 ± 6.47c
300
106.83 ± 1.47
391.21 ± 12.57λ
444.18 ± 16.76λ
245.19 ± 13.78λc
161.27 ± 14.06c
152.18 ± 14.46c
130.22 ± 8.94c
All values are expressed as the mean ± SEM of six animals per experimental group, compared by one-way analysis of variance followed by Tukey test; λ <0.001 means significantly different from the normal control group (nondiabetic); and c <0.001 means significantly different from the diabetic control group.