Antihypernociceptive and Neuroprotective Effects of the Aqueous and Methanol Stem-Bark Extracts of Nauclea pobeguinii (Rubiaceae) on STZ-Induced Diabetic Neuropathic Pain

Table 1

Effects of the aqueous and methanol extracts of the N. pobeguinii on blood glucose level during 6 weeks after injection of streptozotocin in mice.

Treatment	Dose (mg/kg)	Period (week)
		0	1	2	3	4	5	6
Normal control	—	106.67 ± 3.24	104.27 ± 2.18	109.07 ± 5.05	107.67 ± 3.62	104.67 ± 3.93	105.57 ± 2.99	106.40 ± 4.01
Diabetic control	—	104.06 ± 2.82	380.20 ± 8.50^λ	440.03 ± 18.27^λ	446.50 ± 17.88^λ	445.03 ± 20.59^λ	448.23 ± 18.13^λ	456.50 ± 14.27^λ
Pregabalin	30	109.67 ± 4.91	381.00 ± 8.65^λ	434.50 ± 24.89^λ	358.33 ± 13.04^λc	354.33 ± 9.28^λc	357.83 ± 13.19^λc	352.13 ± 11.73^λc
Aqueous extract	150	107.67 ± 0.95	376.00 ± 16.17^λ	438.50 ± 16.55^λ	258.31 ± 16.70^λc	168.00 ± 8.75^c	161.67 ± 5.25^c	136.67 ± 6.07^c
	300	104.83 ± 1.49	366.67 ± 10.18^λ	454.34 ± 18.21^λ	224.88 ± 6.88^λc	133.33 ± 5.50^c	124.50 ± 4.28^c	117.50 ± 5.06^c
Methanol extract	150	105.33 ± 1.61	396.00 ± 11.55^λ	448.04 ± 12.59^λ	285.17 ± 4.07^λc	190.02 ± 19.18^c	176.83 ± 11.03^c	140.17 ± 6.47^c
	300	106.83 ± 1.47	391.21 ± 12.57^λ	444.18 ± 16.76^λ	245.19 ± 13.78^λc	161.27 ± 14.06^c	152.18 ± 14.46^c	130.22 ± 8.94^c

All values are expressed as the mean ± SEM of six animals per experimental group, compared by one-way analysis of variance followed by Tukey test; ^λ <0.001 means significantly different from the normal control group (nondiabetic); and ^c <0.001 means significantly different from the diabetic control group.