Antihypernociceptive and Neuroprotective Effects of the Aqueous and Methanol Stem-Bark Extracts of Nauclea pobeguinii (Rubiaceae) on STZ-Induced Diabetic Neuropathic Pain

Table 2

Effects of the aqueous and methanol extracts of the N. pobeguinii on body weight during 6 weeks after injection of streptozotocin in mice.

Treatment	Dose (mg/kg)	Period (week)
		0	1	2	3	4	5	6
Normal control	—	32.00 ± 0.88	34.00 ± 1.57	36.33 ± 0.80	38.00 ± 0.82	38.50 ± 1.50	40.00 ± 0.93	40.77 ± 0.99
Diabetic control	—	35.67 ± 1.52	33.50 ± 0.81	31.17 ± 0.60^α	30.17 ± 0.89^λ	29.67 ± 0.92^λ	28.17 ± 0.79^λ	27.00 ± 0.52^λ
Pregabalin	30	33.50 ± 1.92	31.17 ± 1.28	30.50 ± 1.29^β	29.50 ± 1.15^λ	28.41 ± 1.43^λ	27.83 ± 1.20^λ	26.09 ± 0.73^λ
Aqueous extract	150	34.12 ± 1.69	33.50 ± 0.96	31.17 ± 0.46^α	32.00 ± 0.37^λ	34.22 ± 0.28	34.50 ± 0.22^βc	35.00 ± 0.58^λc
	300	34.51 ± 2.03	33.67 ± 0.81	31.83 ± 0.52	32.17 ± 0.48^λ	34.33 ± 0.25	36.00 ± 0.32^c	36.67 ± 0.42^βc
Methanol extract	150	35.18 ± 1.37	34.17 ± 1.49	30.67 ± 0.60^β	31.67 ± 0.42^λ	33.00 ± 0.68^α	33.67 ± 0.68^λb	34.08 ± 0.58^λc
	300	32.33 ± 2.17	30.19 ± 1.85	29.40 ± 1.74^λ	29.18 ± 1.50^λ	30.67 ± 1.43^λ	31.33 ± 1.33^λ	32.39 ± 1.15^λc

All values are expressed as the mean ± SEM of six animals per experimental group, compared by one-way analysis of variance followed by Tukey test; ^α <0.05, ^β <0.01, ^λ <0.001 mean significantly different from the normal control group (nondiabetic); and ^b <0.01, ^c <0.001 mean significantly different from the diabetic control group.