Relaxant Effect of Urginea maritima on Tracheal Smooth Muscle Mediated by the Effect on Beta-2 Adrenergic, Muscarinic Receptors and Calcium and Potassium Channels

Figure 1

Concentration-response relaxant effects (mean ± SEM) of theophylline and U. maritima extract in nonincubated TSM contracted by 10 μM methacholine (n = 7). 1, 2, 3, 4, 5, and 6 in X-axis display six concentrations of the extract (12.5, 25, 50, 100, 20, and 400 μg/ml) and 3, 4, 5, and 6 display theophylline concentrations (0.2, 0.4, 0.6, and 0.8 mM) and (b) concentration-response relaxant effects (mean ± SEM) of theophylline and U. maritima extract in glibenclamide-incubated TSM (1 μM, n = 8). and compared to the effect of saline (NS), ⁺ in panel (a) indicates comparison between the effect of theophylline and that of the extract. ⁺ and ⁺⁺ in panel (b) show the comparison of the effect of the extract between incubated and nonincubated tissues. ANOVA with the Tukey–Kramer post hoc test was used for statistical comparison.

(a)

(b)