Ginsenoside Rb3 Alleviates the Toxic Effect of Cisplatin on the Kidney during Its Treatment to Oral Cancer via TGF-β-Mediated Mitochondrial Apoptosis

Figure 7

TGF-β signal pathway was essential to that Rb3 suppressed mitochondrial apoptosis evoked by CPT in GP-293 cells. (a) Flow cytometry of dual-stains of FITC-Annexin V and PI for cell apoptosis ratio. (b) Quantitative analysis for the apoptosis ratio by flow cytometry. (c) Western blotting for the expression level of Bax and Bcl-2. (d) Quantitative analysis of densitometry for the expression of Bax and Bcl-2. Dis, disitertide, an inhibitor of the TGF-β signal pathway. ^# < 0.05 and ^## < 0.01 compared to the CPT group.

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