Hepatoprotective Effects of the Cichorium intybus Root Extract against Alcohol-Induced Liver Injury in Experimental Rats

Figure 5

Effect of Cii on blood-alcohol concentration in rats. (a, b) After 2 weeks of acclimation, the rats received alcohol (40%, 2.5 mL/kg) and Cii by oral injection for (a) 1 and (b) 3 days. The rats were randomly divided into 3 groups (n = 3): CON (distilled water), EtOH (40% EtOH, 2.5 mL/kg), and Cii (EtOH + Cii concentration, 10 mg/kg). Cii was administered at 30 min before EtOH injection. At 1, 7, 12, and 24 h after the EtOH challenge, blood was collected. (c) After 2 weeks of acclimation, the rats received alcohol (40%, 2.5 mL/kg) by oral injection for 50 days. The rats were randomly divided into 5 groups (n = 7): CON (distilled water), EtOH (40% EtOH, 2.5 mL/kg), ECL (EtOH + Cii low concentration, 2 mg/kg), ECH (EtOH + Cii high concentration, 10 mg/kg), and ES (EtOH + silymarin, 100 mg/kg). Data were expressed as mean ± S.E.M. (n = 7). , CON vs. EtOH; , EtOH vs. ECH or ES.

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