Exploring the Therapeutic Mechanism of Tingli Dazao Xiefei Decoction on Heart Failure Based on Network Pharmacology and Experimental Study

<div>Enrichment analysis of TDXD against HF: (a) GO analysis of overlapping targets. The figure lists the top 10 GO pathways in each category. (b) Top 20 pathways of KEGG enrichment analysis. Bubble size represents the number of genes in this pathway, and the color reflects the −log10 (<svg height="8.68572pt" id="M5" style="vertical-align:-0.0498209pt" version="1.1" viewbox="-0.0498162 -8.6359 8.15071 8.68572" width="8.15071pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M600 480C600 590 528 650 384 650H143L137 622C222 614 225 607 210 531L130 127C113 41 106 36 23 28L17 0H294L300 28C204 36 195 42 212 127L243 284L314 263C327 263 339 263 352 264C465 271 600 337 600 480ZM508 481C508 351 402 304 329 304C289 304 265 311 250 317L295 559C302 594 310 606 323 611C335 616 350 619 367 619C455 619 508 573 508 481Z"></path></g></svg> value). (c) Compounds-targets-pathways network. Purple round nodes represent the active components of TDXD. Yellow rhombic nodes represent the gene targets. Green inverted triangle nodes represent the signaling pathways.</div>

Evidence-Based Complementary and Alternative Medicine

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Figure 4

Figure 4: Exploring the Therapeutic Mechanism of Tingli Dazao Xiefei Decoction on Heart Failure Based on Network Pharmacology and Experimental Study 