Involvement of Muscarinic Receptors in Hypotensive and Diuretic Effects of Aqueous Soluble Fraction from Asphodelus tenuifolius Cav.

Figure 5

Effect of the aqueous soluble fraction of A. tenuifolius (AS-AT, 25 mg/kg) on systolic BP in rats pretreated with various antagonists. Results are stated as mean ± SEM, whereas  =  < 0.01 and  =  < 0.001 as compared to normal saline- (NS-) treated group, while a =  < 0.001 when compared to the extract-treated control. The figure shows a decrease in systolic BP with AS-AT (25 mg/kg) in anesthetized rats pretreated with normal saline (NS 1 ml/kg), hexamethonium (30 mg/kg), atropine (2 mg/kg), captopril (2.5 mg/kg), indomethacin (5 mg/kg), L-Name (20 mg/kg), and propranolol (Prop 1 mg/kg).