Bu-Zhong-Yi-Qi Granule Enhances Colonic Tight Junction Integrity via TLR4/NF-κB/MLCK Signaling Pathway in Ulcerative Colitis Rats

Figure 9

TNBS-induced activation of the toll-like receptor (TLR) 4 signal transduction signaling cascade, which leads to the activation of canonical NF-kB pathway. Canonical NF-κB p65/p50 causes upregulation of myosin light chain kinases (MLCK) gene and protein expression, causing MLC phosphorylation, ultimately increasing tight junction (TJ) permeability in vivo. BZYQ treatment may inhibit activation of the toll-like receptor (TLR) 4 signal pathway to maintain intestinal epithelial function.