Aqueous Mulberry Leaf Extract Ameliorates Alcoholic Liver Injury Associating with Upregulation of Ethanol Metabolism and Suppression of Hepatic Lipogenesis

<div>AME supplementation attenuated infiltration of leukocytes and expressions of proinflammatory cytokine IL-6 and TNF<i>α</i> in the liver. Mice were randomly divided into five groups (<i>n</i> = 8 for each group), namely, the control group (normal diet), ethanol group (ethanol diet, the positive control), <i>E </i>+ 0.5% AME group (ethanol diet containing 0.5% AME), <i>E</i> + 1% AME group (ethanol diet containing 1% AME), and <i>E </i>+ 2% AME group (ethanol diet containing 2% AME). After 8-week administration, mice were fasted and sacrificed for the collection of hepatic tissues for (A) histological examination by hematoxylin and eosin staining and (B, C) expression levels of hepatic IL-6 and TNF<i>α</i> by IHC staining.</div>

Evidence-Based Complementary and Alternative Medicine

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Figure 4: Aqueous Mulberry Leaf Extract Ameliorates Alcoholic Liver Injury Associating with Upregulation of Ethanol Metabolism and Suppression of Hepatic Lipogenesis 

Figure 4 | Aqueous Mulberry Leaf Extract Ameliorates Alcoholic Liver Injury Associating with Upregulation of Ethanol Metabolism and Suppression of Hepatic Lipogenesis 