Evidence-Based Complementary and Alternative Medicine

Research Article

GC-MS Characterization of Antibacterial, Antioxidant, and Antitrypanosomal Activity of Syzygium aromaticum Essential Oil and Eugenol

Table 3

Antitrypanosomal activity, BALB/c peritoneal macrophage cytotoxicity, and selectivity index of Syzygium aromaticum essential oil.


Compound	Trypanosoma cruzi IC₅₀ (μg/mL)		Peritoneal macrophage CC₅₀ (μg/mL)	SI
Compound	Epimastigote	Intracellular amastigote	Peritoneal macrophage CC₅₀ (μg/mL)	SI

S. aromaticum essential oil	28.68 ± 1.073^a	64.51 ± 1.658^a	>1000^a	>15.5^a
Eugenol	31.97 ± 1.061^a	45.73 ± 1.252^b	292.7 ± 1.229^b	6.4^b
Benznidazole	1.950 ± 1.066^b	0.4726 ± 1.163^c	187.2 ± 1.125^c	396.1^c

IC₅₀: inhibitory concentration for 50% of parasites; CC₅₀: cytotoxic concentration for 50% of cells; SI: selectivity index, obtained from ratio CC₅₀/IC₅₀ intracellular amastigote. Data represent mean ± standard deviation of at least two independent experiments carried out in triplicate. Different letters in the same column mean statistical difference between groups.