Study on the Molecular Mechanism of the Herbal Couple Sparganii Rhizoma-Curcumae Rhizoma in the Treatment of Lung Cancer Based on Network Pharmacology

Table 2

Information of core targets from bioactive components in HCSC.

UniprotID	Gene targets	Protein targets	MCODE_Score	degree
P02768	ALB	Serum albumin	10.50980392	17
P10275	AR	Androgen receptor	10.3956044	14
Q07817	BCL2L1	Bcl-2-like protein 1	10.50980392	16
P42574	CASP3	Caspase-3	10.50980392	17
Q14790	CASP8	Caspase-8	10.16190476	13
P55211	CASP9	Caspase-9	9.625	15
P24941	CDK2	Cyclin-dependent kinase 2	10.27472527	12
P03372	ESR1	Estrogen receptor	10.50980392	17
P49841	GSK3B	Glycogen synthase kinase-3 beta	11	12
P01112	HRAS	GTPase HRas	10.50980392	16
P07900	HSP90AA1	Heat shock protein HSP 90-alpha	11.42857143	17
P05412	JUN	Transcription factor AP-1	10.50980392	17
Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	9.346405229	14
Q16539	MAPK14	Mitogen-activated protein kinase 14	9.202614379	15
P29474	NOS3	Nitric oxide synthase	10	10
P06401	PGR	Progesterone receptor	10	11
P35354	PTGS2	Prostaglandin G/H synthase 2	11.42857143	16
Q96EB6	SIRT1	NAD-dependent protein deacetylase sirtuin-1	9.625	15