Investigating the Biomarkers of the Sasang Constitution via Network Pharmacology Approach
Table 4
Gene ontology terms of the biological process category associated with Taeeum type.
PANTHER GO-Slim biological process term
Number of genes
p-valued
Combined scoree
Reference lista
Target listb
Expectedc
Response to chemical (GO:0042221)
576
22
4.17
6.11E − 07
108.7424
Cholesterol homeostasis (GO:0042632)
14
6
0.1
4.00E − 06
88.67855
Lipid metabolic process (GO:0006629)
120
10
0.87
2.08E − 05
73.0932
Lipid homeostasis (GO:0055088)
33
6
0.24
1.50E − 04
56.52157
Response to stimulus (GO:0050896)
1190
26
8.61
1.95E − 04
53.73646
Drug metabolic process (GO:0017144)
127
9
0.92
1.86E − 04
53.41338
Response to xenobiotic stimulus (GO:0009410)
40
6
0.29
2.37E − 04
51.07916
Steroid metabolic process (GO:0008202)
44
6
0.32
3.43E − 04
47.94313
Cellular catabolic process (GO:0044248)
111
8
0.8
4.72E − 04
45.28447
Response to drug (GO:0042493)
81
7
0.59
6.04E − 04
43.22787
aNumber of genes in the reference list that map to this PANTHER classification category. bNumber of genes in the target gene list that map to this PANTHER classification category. cThe expected value is the number of genes that can be expected in the target gene list for this PANTHER category based on the reference list. d values are determined by binomial statistics with Benjamini–Hochberg corrections. eCombined score is computed by taking the log of the p-value and multiplying that by the Z-score of the deviation from the expected rank.
