Sauchinone Blocks Ethanol Withdrawal-Induced Anxiety but Spares Locomotor Sensitization: Involvement of Nitric Oxide in the Bed Nucleus of the Stria Terminalis

Figure 3

Effects of Sau on EtOH withdrawal-induced anxiety-like behavior. EtOHW produced anxiety-like behaviors in rats when tested 3 days after the final dose of EtOH, but these behaviors were attenuated by Sau treatment during withdrawal. (a) Total number of entries into open and closed arms of the EPM by rats. (b) Percentage of numbers of entries into open arms of the EPM by rats. (c) Percentage of time spent in open arms by rats. All data are presented as a mean ± SEM (n = 8). S, saline; EtOH, ethanol; Sau, sauchinone; Sau 2.5, 2.5 mg/kg/day Sau; Sau 7.5: 7.5 mg/kg/day Sau; Sau 25, 25 mg/kg/day Sau. and versus the S/vehicle group; versus the EtOH/vehicle group; , , and versus the EtOH/Sau7.5 group (one-way ANOVA followed by the Newman–Keuls post hoc test).

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