Ethanolic Extract of Centella asiatica Treatment in the Early Stage of Hyperglycemia Condition Inhibits Glomerular Injury and Vascular Remodeling in Diabetic Rat Model

Figure 4

Centella asiatica preserved eNOS and down-regulated ACE2 and ppET-1 mRNA expression in DMC2 compared to DM2 groups. (a) The representative pictures of eNOS, ACE2, and ppET-1 based on RT-PCR quantification. (b -d) The bar charts of semiquantitative analysis of eNOS, ppET-1, and ACE2 mRNA expression. <0.01 vs. control, <0.05 vs. control, ^∫<0.01 vs. DM1, ^∫∫<0.05 vs. DM1, ^#<0.01 vs. DM2, and ^##<0.01 vs. DM2.

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