The Treatment of Complementary and Alternative Medicine on Premature Ovarian Failure

Table 2

The summary of randomized clinical studies of compound Chinese medicine on POF.

Prescription	Design	Sample size	Interventions	Outcomes	References
Bushen Shugan recipe	RCT	n = 117	Control group A : Bushen Shugan recipe,; control group B : artificial cycle therapy: estradiol valerate tablet + progesterone capsule,; treatment group: Bushen Shugan recipe combined with artificial cycle therapy	Bushen Shugan recipe combined with artificial cycle therapy can significantly improve serum hormone levels, clinical syndrome scores, and clinical symptoms in patients with POF with kidney deficiency and liver depression syndrome.	[38]
Bushen Tiaojing decoction	Single blind, RCT	n = 110	Control group: hormone replacement therapy,; treatment group: kidney-tonifying prescription	Bushen Tiaojing recipe can effectively reduce the symptoms and signs related to POF, improve reproductive axis status, upregulate GDF-9 and BMP-15 levels, and help to reduce the risk of long-term recurrence.	[40]
Yulin decoction	RCT	n = 60	Control group: sequential estrogen therapy (oral estradiol valerate tablets + progesterone capsules),; treatment group: Yulinzhu	In the treatment of POI (kidney qi deficiency type), Yulinzhu could significantly improve the clinical symptoms, decrease the levels of FSH and LH, increase the level of E2, and increase the number of follicles in the basal antrum of ovary and the thickness of endometrium.	[43]