Thymoquinone Ameliorates Lung Inflammation and Pathological Changes Observed in Lipopolysaccharide-Induced Lung Injury
Table 1
Studied groups, lipopolysaccharide (LPS) administration and thymoquinone (TQ) treatment.
Group
Saline or LPS administration
TQ treatment
Abbreviation
Control
Saline, 2 ml/kg/day, i.p. for two weeks
Saline, 30 min before LPS administration, i.p.
C
LPS administrated
LPS, 1 mg/kg/day, i.p. for two weeks
“
LPS
LPS + TQ 5 mg/kg
“
TQ, 30 min before LPS administration, i.p.
LPS-TQ 5
LPS + TQ 10 mg/kg
“
“
LPS-TQ 10
LPS and TQ were purchased from Sigma Chemical Co. LPS was dissolved in warm sterile saline supplemented with ethanol, and TQ was dissolved in cold sterile saline both freshly prior to injection. The doses of TQ [17, 18] and LPS [12–15] were chosen according previous studies.