Gujiansan Ameliorates Avascular Necrosis of the Femoral Head by Regulating Autophagy via the HIF-1α/BNIP3 Pathway
Table 3
Concentrations of IL-2, TNF-α, IL-6, and CRP in each group on the 2nd, 4th, and 8th weeks (n = 6).
Groups
Week
IL-2 (pg/mL)
TNF-α (pg/mL)
IL-6 (pg/mL)
CRP (ng/mL)
Normal
2
40.53 ± 0.96
3.01 ± 0.71
0.28 ± 0.02
22.12 ± 1.88
4
39.75 ± 1.14
3.29 ± 0.67
0.17 ± 0.084
23.84 ± 1.19
8
39.84 ± 1.16
2.20 ± 0.61
0.33 ± 0.047
21.75 ± 1.65
Model
2
5.63 ± 0.42
47.31 ± 1.81
1.67 ± 0.078
234.98 ± 5.86
4
4.46 ± 0.45
50.67 ± 1.79
1.69 ± 0.015
236.28 ± 4.46
8
3.14 ± 0.34
53.13 ± 1.78
1.79 ± 0.019
244.59 ± 4.83
L-Gujiansan
2
21.73 ± 1.05#
25.21 ± 0.99#
1.15 ± 0.074#
149.95 ± 4.79#
4
22.69 ± 0.89#
26.93 ± 0.73#
1.08 ± 0.045#
136.64 ± 7.75#
8
24.54 ± 0.81#▼
22.81 ± 1.04#▼
0.99 ± 0.054#▼
129.31 ± 7.80#▼
M-Gujiansan
2
24.38 ± 1.30#&
21.36 ± 1.08#&
1.00 ± 0.033#&
118.68 ± 7.40#&
4
25.74 ± 0.81#&
20.62 ± 0.70#&
0.88 ± 0.070#&
116.72 ± 3.99#&
8
27.95 ± 1.01#&▼
16.12 ± 0.86#&▼
0.82 ± 0.063#&▼
107.31 ± 3.98#&▼
H-Gujiansan
2
29.04 ± 1.43#&
16.34 ± 1.03#&
0.78 ± 0.078#&
90.13 ± 4.08#&
4
29.87 ± 0.71#&
14.59 ± 1.17#&
0.78 ± 0.050#&
88.07 ± 9.99#&
8
31.53 ± 0.75#&▼
14.22 ± 1.06#&▼
0.60 ± 0.021#&▼
71.86 ± 7.53#&▼
Pravastatin
2
33.26 ± 1.09#
12.21 ± 0.67#
0.60 ± 0.033#
67.36 ± 5.52#
4
33.36 ± 0.78#
9.89 ± 1.04#
0.53 ± 0.047#
58.33 ± 8.38#
8
35.72 ± 1.04#▼
6.17 ± 0.57#▼
0.43 ± 0.054#▼
50.80 ± 5.76#▼
Data are represented as the means ± SD (n = 6). vs. the normal group. # vs. the model group. & vs. L-Gujiansan corresponding weeks’ group. ▼ vs. corresponding 2 weeks’ group.
