Dendrobium officinale Regulates Fatty Acid Metabolism to Ameliorate Liver Lipid Accumulation in NAFLD Mice

Figure 4

DOFP regulated FA metabolism in the liver of mice with DOFP 3 weeks of intervention. (a) FA species in the liver. (b) Biochemical pathway related to FA metabolism and ratios regulated by DOFP. Green arrows represent the ratios significantly elevated in the MG but attenuated by DOFP, while the red arrows represent the ratios significantly lowered in model group but elevated by DOFP. (c) Ratios of C20 : 4/C20 : 3 and C22 : 4/C22 : 3 in the liver. (d) Ratios of C16 : 0/C14 : 0 and C18 : 1/18 : 0 in the liver. (e) CPT1-α, FATP2, and FAS expression in the liver by western-blot analysis. (f) Quantitative analysis of FATP2, CPTI-α, and FAS protein levels. (g), (h) SCD-1 and ACOX-1 expression in the liver by IHC observed at magnification 400x. Significant differences are indicated by and as compared with the normal group (NG), and and P < 0.01 as compared with the model group (MG) (n = 3∼4 per group).

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