Metabonomic Study on the Plasma of High-Fat Diet-Induced Dyslipidemia Rats Treated with Ge Gen Qin Lian Decoction by Ultrahigh-Performance Liquid Chromatography-Mass Spectrometry
Table 5
Potential biomarkers in positive ion mode.
Biomarker
Formula
m/z
RT (min)
VIP
Model group
Administered group
Indole acetaldehyde
C10 H9 N O
160.0743
1.71
1.34
↓##
↑
Acylglycine
C9 H9 N O3
180.0646
4.17
1.65
↓##
↑
Iso-L-carnitine
C11 H21 N O4
232.1534
2.39
1.28
↓##
↓
α-Linolenic acid
C18 H30 O2
279.2301
14.55
1.62
↓##
↑
(Z)-13-octadecenoic acid
C18 H34 O2
283.2628
17.16
1.64
↑##
↓
Androstenone 3α, 17β-diol
C15 H28 N6
293.2458
13.51
1.47
↓##
↑
Arachidonic acid
C20 H32 O2
305.2472
15.51
1.24
↑##
↓
Octadecanoic acid
C18 H36 O2
307.2604
16.39
1.06
↑##
↓
L-Octyl carnitine
C16 H25 N5
310.1997
5.74
1.74
↑##
↓
Docosapentaenoic acid
C22 H34 O2
331.2622
12.41
1.41
↑#
↑
Arachidonic acid ethanolamine
C22 H37 N O2
348.2889
16.32
1.30
↑#
↓
Ethyl acetate arachidonic acid
C22 H36 O2
355.2614
6.85
1.08
↓##
↑
Tetracosahexaenoic acid
C24 H36 O2
357.2768
7.98
1.28
↓##
↓
N-Acetylethanolamine
C24 H36 O3
373.2722
6.81
1.45
↓##
↑
7-Ketodeoxycholic acid
C24 H38 O5
407.2781
6.47
1.32
↓#
↑
Stearyl carnitine
C21 H45 N7 O2
428.3719
9.32
1.60
↑##
↓
LysoPC (14 : 0/0 : 0)
C24 H41 N3 O6
468.307
7.67
1.32
↓#
↓
LysoPE (20 : 4 (5Z, 8Z, 11Z, 14Z)/0 : 0)
C25 H44 NO7P
502.2919
8.49
1.60
↑#
↓
LysoPE (20 : 1(11Z)/0 : 0)
C27 H45 N3 O6
508.3371
8.72
1.59
↓##
↓
LysoPC (20 : 5 (5Z, 8Z, 11Z, 14Z, 17Z))
C30 H43 N3 O6
542.3227
7.82
1.65
↓##
↑
LysoPC (22 : 4 (7Z, 10Z, 13Z, 16Z))
C32 H49 N3 O6
572.3698
9.89
1.59
↑##
↑
LysoPC (24 : 1(15Z))
C35 H55 N7 O2
628.4311
17.04
1.51
↓##
↓
SM (D18 : 1/14 : 0)
C39 H70 N4 O5
697.5252
19.17
1.67
↑##
↓
Note. “↓” means decreased, “↑” means increased; compared with the normal group, and ; compared with model group, and .
