Review Article

Acupuncture Treatment for Cough-Variant Asthma: A Meta-Analysis

Table 2

Basic information of included studies.

AuthorInterventionsControl groupThe number of cases/caseGender (male/female)AgePeriod of treatment (d)Diagnostic criteria and efficacy criteriaOutcome indicatorsFollow-up timeRegion
Experimental groupControl group

Zhang 2017 [8]① + ②505063/3718–6056(1), (2)Symptom score (cough score, sputum score, diaphragmatic fullness score), lung function (PEF, FVC, FEV1), total effective rate, adverse reactionsNot mentionedChina’s Hebei province

Zheng 2014 [9]⑩ + ③404057/6215–6710 d(1), (3)Total response rate, lung function (FVC, FEV1, PEF), general adaptive quality of life questionnaire dimensions and total scores, specific quality of life questionnaire scores in all areas, and LCQ total scoresNot mentionedChina’s Hubei province

Zhang 2015 [10]① + ④606067/536–5290(4)Total effective rateNot mentionedChina’s Liaoning province

Zhang 2017 [11]⑩ + ① + ⑤ + ⑥① + ⑤ + ⑥404048/3218–5928(1), (2), (3)CRP, IL-6, TNF-, total response rate, symptom score (cough, sputum, diaphragmatic fullness)Not mentionedChina’s Hebei province

Dong 2012 [12]① + ②494934/6419–7214(4)Total effective rate, time for improvement of clinical symptoms and signs (dry cough, expectoration, chest tightness, wheezing)Not mentionedChina Ningxia

Zhang 2019 [13]⑩ + ⑨303232/301–1414(2), (7), (8), (9), (10), (11)Cough symptom score, (self-modified) TCM syndrome score, effective rate of cough symptom score, effective rate of TCM syndrome score, 3-month recurrence rate, 3-month follow-up score of digestive tract symptoms3 monthsChina’s Fujian province

Lin 2018 [14]④ + ⑤313024/3718–7014(2), (10), (12)Total effective rate, score of cough symptoms, score of comparison of symptoms and signs, total score of symptoms, IgE, safety indexNot mentionedChina’s Fujian province

Shi 2020 [15]⑩ + ①303031/413–1228(2), (8), (9)Total effective rate, IgE, TCM symptom score, 6-month recurrence rate, safety index6 monthsChina's Fujian province

Gong 2019 [16]⑩ + ⑨303039/2162–8230DescribeTotal effective rate, IgA, IgG, lung function (PEF, FEV1), cough disappearance time, length of hospital stay, adverse reactionsNot mentionedChina’s Sichuan province

Li 2017 [17]⑩ + ⑨646467/6159–8221DescribeTotal effective rate, duration of asthma, time of disappearance of cough, time of disappearance of pulmonary wheezing, adverse reactions, recurrence rate, adverse reactionsNot mentionedChina’s Guangdong province

Zhu 2016 [18]⑩ + ① + ⑤ + ⑥① + ⑤ + ⑥404048/3218–5728(1), (2), (3)CRP, IL-8, TNF-, total response rate, symptom score (cough, sputum, diaphragmatic fullness), pulmonary function (FVC, FEV1, PEF)Not mentionedChina’s Hebei province

Note: ① montelukast sodium; ② cloth DE resistance; ③ pulmonary function rehabilitation training; ④ forticasone propionate; ⑤ salmeteroticasone; ⑥ terbutaline; ⑦ albuterol; ⑧ aminophylline; ⑨ traditional Chinese medicine medicinal broth; ⑩ acupuncture. Diagnostic and therapeutic criteria: ⑴ 2009 Guidelines for Diagnosis and Treatment of Cough; ⑵ Guiding Principles for Clinical Research of New Chinese Medicines; (3) Diagnostic and Curative Effect Criteria of TCM Diseases and Syndromes; ⑷ Guidelines for the Prevention and Treatment of Bronchial Asthma; ⑸ Guide to Diagnosis and Treatment of Chronic Cough in Children (2013); ⑹ “TCM Clinical Diagnosis and Treatment Terminology Syndrome Part”; ⑺ Paediatrics of Traditional Chinese Medicine; ⑻ Guidelines for the Diagnosis and Treatment of Bronchial Asthma in Children; ⑼ Clinical Diagnosis and Treatment Guidelines for Chinese Medicine Paediatrics Children’s Cough-Variant Asthma (developed); ⑽ 2015 Diagnostic and Treatment Guidelines for Cough; ⑾ Clinical Research Points of Traditional Chinese Medicine for Paediatric Diseases; ⑿ Practical Traditional Chinese Medicine Internal Medicine.