Salvia miltiorrhiza (SM) Injection Ameliorates Iron Overload-Associated Cardiac Dysfunction by Regulating the Expression of DMT1, TfR1, and FP1 in Rats

Figure 2

Effects of SM injection on morphological changes in heart tissue. Samples were obtained from the control group (saline), iron overload (IO) group (iron dextran 50 mg/kg), high-dose SM group (H-SM, iron dextran 50 mg/kg + SM 6 g/kg), low-dose SM group (L-SM, iron dextran 50 mg/kg + SM 3 g/kg), and DFO group (iron dextran 50 mg/kg + DFO 100 mg/kg). The cell nucleus swelled (black arrow) together with myocardial fibers, which resulted in atrophy and rupture (white arrows) as shown by H&E staining (magnification 200x, scale bar = 100 μm).