Protective Effect of Joa-Gui Em through the Improvement of the NLRP3 and TLR4/NF-κb Signaling by Ischemia/Reperfusion-Induced Acute Renal Failure Rats

Table 3

Effect of JGE on renal functional parameters.

	Cont	ARF	ARF + JGE100	ARF + JGE200
BUN/Cr	31.86 ± 1.14	52.27 ± 1.73^∗∗∗	43.82 ± 2.13	43.46 ± 0.88
Ccr (ml/min/kg)	0.46 ± 0.03	0.26 ± 0.02^∗∗∗	0.33 ± 0.03	0.34 ± 0.02
LDH (U/L)	1612.7 ± 150.7	2089.2 ± 136.6^∗	1474.5 ± 108.6	1104.9 ± 102.7

Cont., control; ARF, ischemia/reperfusion- (I/R-) induced acute renal failure (ARF) group; ARF + JGE100, JGE 100 mg/kg/day; ARF + JGE200, JGE 200 mg/kg/day for 4 days; Cr, creatinine; Ccr, creatinine clearance; BUN, blood urea nitrogen; LDH, lactate dehydrogenase. Values are expressed as mean ± SE. (n = 10). ^∗∗∗ vs. cont.; , , vs. ARF.