Anti-Inflammatory and Anti-Vascular Leakage Effects by Combination of Centella asiatica and Vitis vinifera L. Leaf Extracts

Figure 9

Representative immunohistochemical findings of COX-2 and iNOS on the paw tissues 5 h after carrageenan injection. (a), (b) Marked increases of COX-2 and iNOS positive cells were observed on the dermis of hind footpads in carr-injected mice compared with normal mice. However, these increases of dermal COX-2 and iNOS positive cells were effectively decreased by treatment with dexamethasone and were also dose-dependently affected by treatment with CE, VVE, and CE-VVE combinations. In comparison of extract-treated groups, the CE-VVE 1 : 3 combination shows the best efficacy in paw inflammation. (c), (d) Numbers of COX-2 and iNOS positive cells in the dermis of paw tissues are plotted as mean ± SD, , vs. carr-injected group, respectively (original magnification at ×400).

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