Antiplatelet Therapy with Integrated Traditional Chinese and Western Medicine for Use in Myocardial Ischemia-Reperfusion Injury: A Review of Clinical Applications and Mechanisms

Table 1

Summary of randomized studies on the effects of TCM formulations on CHD.

Studies	Interventions	Dose	Duration (months)	Result	Mechanism
Li et al. [40]	E: CDDP + PCI + conventional treatment; C: PCI + conventional treatment	CDDP: 10 pills, tid	3 months	Combined CDDP may reduce the incidence of MACE in patients	—
Wang [41]	E: CDDP + aspirin; C: aspirin	CDDP: 10 pills, tid; Aspirin: 50–150 mg daily	3 months	CDDP combined with aspirin is effective in increasing the efficacy of CHD patients	Reducing the rate of platelet aggregation, inhibiting platelet aggregation, and reducing thromboxane formation
Yan [42]	E: CDDP + PCI + aspirin; C: aspirin	CDDP: 10 pills, tid; Aspirin: 100 mg daily	3 months	CDDP improves cardiac function and reduces the incidence of major long-term cardiovascular events in patients	Improved myocardial microcirculation
Wei et al. [43]	E: DAPT + CDDP; C1: DAPT + bivalirudin; C2: DAPT + bivalirudin + CDDP	CDDP: 10 pills, tid	1 week	The combination group was able to improve cardiac function	—
Tsai et al. [44]	E: DAPT + CDDP; C1: clopidogrel; C2: DAPT	CDDP: 10 pills, tid; Clopidogrel: 75 mg daily; Aspirin: 100 mg daily	3 weeks	Better improvement of symptoms in patients with unstable angina in the combination group	By downregulating platelet aggregation rate and thromboxane B2
Bo and Hui [45]	E: DAPT + Naoxintong capsules; C: DAPT	Naoxintong capsules: 1.6 g, tid	1 week	Attenuates myocardial injury after PCI	Through anti-inflammatory effects
Chen et al. [46]	E: Naoxintong capsules + aspirin; C: aspirin	Aspirin: 100 mg daily; Naoxintong capsules: 3 pills, tid	1 month	Inhibition of platelet activity by Naoxintong capsules is superior to aspirin alone	—
Ming et al. [47]	E: Naoxintong capsules + DAPT; C: DAPT	Clopidogrel: 75 mg daily; Aspirin: 100 mg daily; Naoxintong capsules: 3 pills, tid	5 days	The combination achieves more desirable antiplatelet aggregation without increasing the risk of bleeding	—
Lengqin and Yinghong [48]	E: DHI + conventional therapy; C: conventional therapy	DHI: 30 ml daily	14 days	DHI can effectively improve the microcirculation state	—
Qi [49]	E: DHI + conventional therapy; C: conventional therapy	DHI: 40 ml daily	6 days	DHI reduces myocardial infarct size and has the effect of improving cardiac function in perioperative patients undergoing PCI	—
Chen-guang et al. [50]	E: DHI + conventional therapy; C: conventional therapy	DHI: 40 ml daily	2 weeks	The effect of the experimental group was better	Improved levels of inflammatory factors in patients and the inhibition of platelet activation as well as improved endothelial function
Xiaoli and Jianjun [51]	E: STS + aspirin; C: aspirin	STS: 16 ml daily; Aspirin: 100 mg daily	2 weeks	STS can improve clinical symptoms	STS can significantly inhibit platelet activation function
Qing [52]	E: STS + DAPT; C: DAPT	Aspirin: 100 mg daily; Clopidogrel: 75 mg daily; STS: 80 mg daily	4 weeks	STS can reduce angina recurrence	STS can improve the inflammatory response, reduce blood viscosity, and protect cardiomyocytes
Tao [53]	E: STS + DAPT; C: DAPT	Aspirin: 100 mg daily; Clopidogrel: 75 mg daily; STS: 100 ml daily	40 days	STS is effective in improving outcomes in ACS patients undergoing PCI	—

E: experimental group; C: control group; tid: three times per day; CDDP: Compound Danshen Dripping Pill; PCI: percutaneous coronary intervention; DAPT: dual antiplatelet therapy; DHI: Danhong injection; STS: sodium tanshinone IIA sulfonate injection.