Quercetin Protects H9c2 Cardiomyocytes against Oxygen-Glucose Deprivation/Reoxygenation-Induced Oxidative Stress and Mitochondrial Apoptosis by Regulating the ERK1/2/DRP1 Signaling Pathway

Figure 1

Low concentration of QCT promotes proliferation and inhibits oxidative stress response in OGD/R-induced H9c2 cells. The (a, b) viability, (c) MDA level, (d) SOD level, (e) eNOS level, and (f) proportion of H9c2 cells with increased ROS. Cells were cultured with different concentrations of QCT or NAC and subsequently cultured for 6 h in glucose-free DMEM (TBD) at 37°C with 5% CO₂, 5% O₂, and 90% N₂; thereafter, the cells were cultured for 24 h in DMEM (HyClone) supplemented with 10% FBS (Gibco) and maintained at 37°C with 5% CO₂ and 95% air. Data were presented as the mean ± SD, n = 3, vs. the control group, and ^ vs. the OGD/R group.

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