Development of an Innovative Berberine Food-Grade Formulation with an Ameliorated Absorption: In Vitro Evidence Confirmed by Healthy Human Volunteers Pharmacokinetic Study

<table class="table-group" id="tab1"><tr><td><table class="table"><tr><td class="thead-hr" colspan="4"><hr/></td></tr><tr class="thead"><td class="align_left" rowspan="2">Material</td><td class="align_center">FaSSGF</td><td class="align_center">FeSSIF</td><td class="align_center">FaSSIF</td></tr><tr class="thead"><td class="align_center" colspan="3">Berberine (mg/mL)</td></tr><tr><td class="thead-hr" colspan="4"><hr/></td></tr><tr><td class="align_left">BBR-PP</td><td class="align_center">0.603</td><td class="align_center">0.329</td><td class="align_center">0.365</td></tr><tr><td class="align_left">Berberine extract</td><td class="align_center">0.188</td><td class="align_center">0.129</td><td class="align_center">0.149</td></tr><tr class="table-tr"><td colspan="4"><hr class="tbody-hr"/></td></tr></table></td></tr><tr class="table-fn"><td><div>Solubility studies were performed in FaSSGF (fasted-state simulated gastric fluid) at pH 1.6; FaSSIF (fasted-state simulated intestinal fluid) at pH 6.5, or FeSSIF (fed-state simulated intestinal fluid) at pH 5.0.<br/></div></td></tr></table>

<div>Solubility studies in gastric simulated fluids.</div>

Evidence-Based Complementary and Alternative Medicine

tab1

Table 1

Table 1: Development of an Innovative Berberine Food-Grade Formulation with an Ameliorated Absorption: In Vitro Evidence Confirmed by Healthy Human Volunteers Pharmacokinetic Study 

Table 1 | Development of an Innovative Berberine Food-Grade Formulation with an Ameliorated Absorption: In Vitro Evidence Confirmed by Healthy Human Volunteers Pharmacokinetic Study 