Research Progress on the Antiosteoarthritic Mechanism of Action of Natural Products

Figure 6

Animal models, cell models, and signaling pathways involved in the study of natural products with antiosteoarthritis effect. (a) Animal models used in the study of osteoarthritis. (b) Cell models used in the study of osteoarthritis. (c) Signaling pathways involved in the study of the mechanisms of natural products with antiosteoarthritis. The antiosteoarthritis mechanism of most natural products is related to the 2 signaling pathways marked in red. Some are related to the 3 signaling pathways marked in blue. A few are related to the 5 signaling pathways marked in green. ACLT: anterior cruciate ligament; MIA; injection of sodium iodoacetate; MNX; medial meniscectomy; DMM; destabilization of medial meniscus; MMxs; resection of medial menisci.

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