Research Progress on the Antiosteoarthritic Mechanism of Action of Natural Products

Table 1

Natural products of terpenoids with antiosteoarthritis function.

Compound	Source	Cell/animal model	Effect	Ref
Aucubin	Eucommia ulmoides, Plantago asiatica, Rehmannia glutinosa	IL-1β-induced porcine chondrocytes/chondrocytes of male C57BL/6 mice induced by DMM	Maintain ACAN and COL2A1 gene expressions, prevent IL-6 and MMP-13 gene upregulation, reduce the caspase-3 activity, and downregulate Bax, caspase-9 and caspase-3	[32]
Abietic acid	Colophonium	Human OA chondrocytes	Inhibited IL-1β-induced TNF-α, NO, PGE2 production, and COX-2 expression, suppressed MMP-1, MMP-3, and MMP-13 production	[33]
Andrographolide	Andrographis paniculata	Chondrocytes of SD rats induced by H2O2	Upregulate expression of SOD and decrease MDA activity, MMP-13, TIMP-1, and Il-6	[49]
Celastrol	Celastrus orbiculatus, Tripterygium wilfordii	Chondrocytes of SD rats/male SD rats induced by ACLT	Ameliorate IL-1β-induced chondrocyte apoptosis and increased the expression of LC3-II and Beclin-1 and, moreover, decrease the phosphorylation degree of IκBα and P65	[84]

DMM: destabilization of medial meniscus; ACLT: anterior cruciate ligament.