Phytochemical Analysis Using UPLC-MS/MS Combined with Network Pharmacology Methods to Explore the Biomarkers for the Quality Control of Lingguizhugan Decoction

Table 4

Regression equations, correlation coefficients, linear ranges, LODs, and LOQs of 20 chemical constituents.

<!-Col Count:6-->Chemical components	Calibration curve	R^2	Linearity range (μg/mL)	LOD (ng/mL)	LOQ (ng/mL)
Poricoic acid A	Y = 72391X − 5034.7	0.9994	0.002∼0.21	0.199	0.665
Poricoic acid B	Y = 68768X − 7167.6	0.9989	0.002∼0.22	0.177	0.591
Glycyrrhizic acid	Y = 229221X − 89186	0.9970	2.829∼282.9	499.2	1664
Glycyrrhetinic acid	Y = 76305X + 1723.8	0.9995	0.003∼0.32	0.461	1.538
Liquiritin	Y = 1E + 06X  − 97606	0.9952	3.264∼326.4	90.08	300.3
Isoliquiritin	Y = 472548X − 40833	0.9988	0.042∼42.12	12.74	42.46
Liquiritigenin	Y = 1E + 06X + 1E + 06	0.9959	2.465∼61.63	28.94	96.48
Isoliquiritin apioside	Y = 601173X − 225511	0.9950	0.536∼53.62	26.81	89.37
Cinnamic acid	Y = 751463X + 182882	0.9939	0.768∼76.80	157.8	526.0
Caffeic acid	Y = 5E + 06X + 1E + 06	0.9945	0.017∼1.697	1.858	6.192
Neochlorogenic acid	Y = 3E + 06X − 953535	0.9963	0.166∼16.55	5.623	18.72
Chlorogenic acid	Y = 4E + 06X − 961985	0.9978	0.162∼16.15	2.525	8.416
Cryptochlorogenic acid	Y = 3E + 06X + 88218	0.9960	0.055∼5.528	1.229	4.096
Isochlorogenic acid A	Y = 31732X − 10255	0.9971	0.039∼3.894	4.314	14.38
Isochlorogenic acid B	Y = 33.14X + 17963	0.9997	0.024∼2.430	8.404	28.01
Isochlorogenic acid C	Y = 48826X − 11262	0.9937	0.034∼3.353	7.288	24.29
Atractylenolide III	Y = 628413X − 27614	0.9996	0.060∼6.000	3.379	11.26
Atractylenolide I	Y = 78592X − 1874.8	0.9995	0.033∼3.300	18.80	62.67
Atractylenolide II	Y = 345026X + 43919	0.9986	0.094∼9.400	13.95	46.51
Coumarin	Y = 731434X − 14528	0.9998	0.274∼27.36	241.41	804.7