Tanshinone I Mitigates Steroid-Induced Osteonecrosis of the Femoral Head and Activates the Nrf2 Signaling Pathway in Rats

Figure 2

TsI promotes osteogenesis in the femoral heads of the MPS-induced SIONFH rat model. (a) ALP activity in the femoral heads. (b) mRNA levels of OCN, COL I, OPN, and Runx2 in the femoral heads. (c) Expression levels of OCN, COL I, OPN, and Runx2 in the femoral heads. (d) Representative images of OCN staining and COL I staining (scale bar, 200 μm) in the femoral heads. , ; , ; ns, no significant. ALP, alkaline phosphatase; OCN, osteocalcin; COL I, type I collagen; OPN, osteopontin; Runx2, Runt-related transcription factor 2.

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