Research Article
Tanshinone I Mitigates Steroid-Induced Osteonecrosis of the Femoral Head and Activates the Nrf2 Signaling Pathway in Rats
Figure 5
TsI inhibits oxidative stress and activates the Nrf2 signaling pathway in the MPS-induced SIONFH rat model. (a–c) SOD, GSH-Px, and CAT activities in the femoral heads. (d–f) Expression levels of nuclear Nrf2, HO-1, and NQO1 in the femoral heads. 1, the control group; 2, the SIONFH group; 3, the SIONFH + TsI-L group; 4, the SIONFH + TsI-H group. ; ns, no significant. SOD, superoxide dismutase; GSH-Px, glutathione peroxidase; CAT, chloramphenicol acetyltransferase; Nrf2, nuclear factor erythroid 2-related factor 2; HO-1, heme oxygenase; NQO1, NADPH quinone dehydrogenase 1.
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