Main Active Components and Cell Cycle Regulation Mechanism of Astragali Radix and Angelicae Sinensis Radix in the Treatment of Ox-LDL-Induced HUVECs Injury and Inhibition of Their Cell Cycle

Figure 5

Expression of cyclins at the mRNA level in HUVECs was determined by qRT-PCR. Results represent the mean of three independent experiments (n = 3). A1 to A6 indicate the expression of cyclin A at the mRNA level. B1 to B6 represent the expression of cyclin B at the mRNA level. C1 to C6 show the expression of cyclin D at the mRNA level. D1 to D6 display the expression of cyclin E at the mRNA level. Results are expressed as the mean ± standard deviation of independent experiments performed in triplicate and normalized to control. AS IV: astragaloside IV; AS I: astragaloside I; FRM: formononetin; CAL: calycosin; CLG: calycosin-7-O-β-D glucoside; FRA: ferulic acid; active components (−): active component knock-out; ACC: active component combination. vs. control; , , vs. model.

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