Main Active Components and Cell Cycle Regulation Mechanism of Astragali Radix and Angelicae Sinensis Radix in the Treatment of Ox-LDL-Induced HUVECs Injury and Inhibition of Their Cell Cycle

Figure 6

Effect of the six active components on the expression of CDKs at the mRNA level in HUVECs. The expression at the mRNA level was evaluated by qRT-PCR, and the data represent the average of three experimental results (n = 3). A1 to A6 represent the expression of CDK1 at the mRNA level. B1 to B6 display the expression of CDK2 at the mRNA level. C1 to C6 represent the expression of CDK4 at the mRNA level. D1 to D6 show the expression of CDK6 at the mRNA level. AS IV: astragaloside IV; AS I: astragaloside I; FRM: formononetin; CAL: calycosin; CLG: calycosin-7-O-β-D glucoside; FRA: ferulic acid; active components (−): active component knock-out; ACC: active component combination. , vs. control; , , vs. model.

(a)

(b)

(c)

(d)