Schisandrin Protects against Norepinephrine-Induced Myocardial Hypertrophic Injury by Inhibiting the JAK2/STAT3 Signaling Pathway

Figure 1

(a) (Scale bar: 500 μm) morphological changes of myocardial cells in each group were studied; control: H9C2 cells growth without any treatment; model: norepinephrine-induced myocardial hypertrophic injury and without any treatment. Coptopril: H9C2 cells were pretreated with captopril. Different dosages of SCH were administrated in the cell model with myocardial hypertrophic injury (Ld-SCH, Md-SCH, and Hd-SCH). (b) The applied MTT assay for the determination of the effect of schisandrin pretreatment on NE-treated cardiomyocyte survival. SCH, schisandrin; Ld, low dose; Md, medium dose; Hd, high dose; a,  < 0.05 vs. the control group; b,  < 0.05 vs. the model group; c,  < 0.05 vs. the captopril group; and d,  < 0.05 vs. the medium-dose schisandrin group.

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