Protective Effect of Xiao-Xu-Ming Decoction-Mediated Inhibition of ROS/NLRP3 Axis on Lipopolysaccharide-Induced Acute Lung Injury <i>In Vitro</i> and <i>In Vivo</i>

<div>Effects of XXMD on ROS production, hyperpermeability, and NLRP3 inflammasome in HPAEpiC after NLRP3 overexpression. (a, b) HPAEpiC were transduced with pLVX-Puro-NLRP3, and the level of NLRP3 was detected. These cells were transduced with pLVX-Puro-NLRP3 or blank pLVX-Puro vector and then treated with XXMD (1 mg/mL) for 24 h and (c) the cell viability analysis, (d) TEER, (e) FITC permeability, (f, g) the expression level of ZO-1, CLDN4, NLRP3, and caspase 1, and (h) the levels of IL-1<i>β</i> and IL-18 were determined. 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Evidence-Based Complementary and Alternative Medicine

fig2

Figure 2

Figure 2: Protective Effect of Xiao-Xu-Ming Decoction-Mediated Inhibition of ROS/NLRP3 Axis on Lipopolysaccharide-Induced Acute Lung Injury <i>In Vitro</i> and <i>In Vivo</i> 

Figure 2 | Protective Effect of Xiao-Xu-Ming Decoction-Mediated Inhibition of ROS/NLRP3 Axis on Lipopolysaccharide-Induced Acute Lung Injury In Vitro and In Vivo 