Study on the Mechanism of Reducing Hepatotoxicity of Water-Grinding Realgar by Metabolomics, Morphology, and Chemical Analysis

Figure 5

Box plots of biomarkers from plasma samples of six groups. The data are presented as means ± SD. (a) Chenodeoxycholic acid glycine conjugate. (b) Arachidonic acid. (c) Phosphorylcholine. (d) Chenodeoxycholic acid. (e) Cholic acid. (f) Glycocholic acid. (g) Linoleic acid. (h) Stearic acid. (i) Taurocholic acid. (j) LysoPC (16 : 0/0 : 0). (k) LysoPC (P-18 : 0/0 : 0). (l) Choline. (m) 5-Methoxyindoleacetate. (n) Palmitoyl L-carnitine.  < 0.05,  < 0.01,  < 0.001,  < 0.0001, significant difference compared with control group (Group C). # < 0.05, ## < 0.01, significant difference compared with Group CC. The Welch ANOVA followed by Tukey's multiple comparison test or Student–Newman–Keuls (SNK) test was used for statistical analysis.  < 0.05 was considered statistical significance.

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