Study on the Mechanism of Reducing Hepatotoxicity of Water-Grinding Realgar by Metabolomics, Morphology, and Chemical Analysis

Table 1

The grouping of experimental animals.

Groups	Subgroups	Exposure
Control groups (n = 12)	Control group (Group C, n = 6)	0.5% (w/v) CMC-Na, 10 mL/kg/day, 30 days.
	Convalescent control group (Group CC, n = 6)	0.5% (w/v) CMC-Na, 10 mL/kg/day, 30 days; normal breeding, 7 days.
Grinding-realgar groups (n = 24)	Low-grinding-realgar group (Group LG-r, n = 6)	G-r, 0.64 g/kg/day, 30 days.
	Low-grinding-realgar convalescent group (group CLG-r, n = 6)	G-r, 0.64 g/kg/day, 30 days; normal breeding, 7 days.
	High-grinding-realgar group (Group HG-r, n = 6)	G-r, 1.92 g/kg/day, 30 days.
	High-grinding-realgar convalescent group (Group CHG-r, n = 6)	G-r, 1.92 g/kg/day, 30 days; normal breeding, 7 days.
Water-grinding-realgar groups (n = 24)	Low-water-grinding-realgar group (Group LWG-r, n = 6)	WG-r, 0.64 g/kg/day, 30 days.
	Low-water-grinding-realgar convalescent group (Group CLWG-r, n = 6)	WG-r, 0.64 g/kg/day, 30 days; normal breeding, 7 days.
	High-water-grinding-realgar group (Group HWG-r, n = 6)	WG-r, 1.92 g/kg/day, 30 days.
	High-water-grinding-realgar convalescent group (Group CHWG-r, n = 6)	WG-r, 1.92 g/kg/day, 30 days; normal breeding, 7 days.