Bioinformatics and Network Pharmacology-Based Approaches to Explore the Potential Mechanism of the Antidepressant Effect of Cyperi Rhizoma through Soothing the Liver
Table 2
Details of top 5 GO and KEGG enrichment terms.
Ontology
ID
Description
GeneRatio
BgRatio
P value
p. adjust
Q value
BP
GO:0032496
Response to lipopolysaccharide
26/106
330/18670
1.12e − 22
4.32e − 19
1.78e − 19
BP
GO:0002237
Response to molecule of bacterial origin
26/106
343/18670
3.01e − 22
5.81e − 19
2.39e − 19
BP
GO:0031667
Response to nutrient levels
28/106
499/18670
2.05e − 20
2.64e − 17
1.09e − 17
BP
GO:0001505
Regulation of neurotransmitter levels
24/106
354/18670
2.03e − 19
1.96e − 16
8.08e − 17
BP
GO:0010038
Response to metal ion
24/106
364/18670
3.88e − 19
2.67e − 16
1.10e − 16
CC
GO:0045121
Membrane raft
20/106
315/19717
3.61e − 16
5.23e − 14
3.46e − 14
CC
GO:0098857
Membrane microdomain
20/106
316/19717
3.84e − 16
5.23e − 14
3.46e − 14
CC
GO:0098589
Membrane region
20/106
328/19717
7.88e − 16
7.14e − 14
4.73e − 14
CC
GO:0099055
Integral component of postsynaptic membrane
12/106
117/19717
1.48e − 12
1.00e − 10
6.65e − 11
CC
GO:0098936
Intrinsic component of postsynaptic membrane
12/106
122/19717
2.45e − 12
1.33e − 10
8.81e − 11
MF
GO:0030594
Neurotransmitter receptor activity
14/106
117/17697
8.72e − 15
3.77e − 12
2.32e − 12
MF
GO:0070405
Ammonium ion binding
11/106
75/17697
7.45e − 13
1.61e − 10
9.93e − 11
MF
GO:0005126
Cytokine receptor binding
15/106
286/17697
1.61e − 10
2.32e − 08
1.43e − 08
MF
GO:0002020
Protease binding
11/106
128/17697
2.85e − 10
3.08e − 08
1.90e − 08
MF
GO:0005125
Cytokine activity
13/106
220/17697
6.83e − 10
5.90e − 08
3.64e − 08
KEGG
hsa04933
AGE-RAGE signalling pathway in diabetic complications
