Effectiveness and Safety of the Korean Medicine Senior Health Promotion Program Using Herbal Medicine and Acupuncture for Mild Cognitive Impairment: A Retrospective Study of 500 Patients in Seoul, Korea

Table 4

Effectiveness of adjunctive herbal medicine decoction according to type of herbal medicine formula.

Variables

Guibi-tang (modified or not)

Cheonwangbosim-dan

Jowiseungcheong-tang

Hwangnyeonhaedok-tang

Pre

Post

value

Cohen’s d

Pre

Post

value

Cohen’s d

Pre

Post

value

Cohen’s d

Pre

Post

value

Cohen’s d

Overall

MoCA-K

17.60 ± 3.76 (299)

20.22 ± 4.88 (299)

<0.0001

0.79

18.40 ± 3.37 (10)

21.20 ± 5.63 (10)

0.0781

0.66

16.72 ± 4.37 (36)

18.53 ± 5.50 (36)

0.0007

0.61

17.11 ± 4.65 (9)

22.56 ± 4.22 (9)

0.0039

1.40

MMSE-DS

23.52 ± 3.71 (299)

25.55 ± 3.51 (299)

<0.0001

0.66

24.50 ± 2.95 (10)

26.30 ± 2.26 (10)

0.0156

0.77

22.69 ± 4.09 (36)

24.50 ± 3.80 (36)

<.0001

0.78

23.22 ± 3.42 (9)

26.44 ± 2.55 (9)

0.0156

1.24

GDSSF-K

7.40 ± 4.15 (299)

5.52 ± 4.00 (299)

<0.0001

−0.64

8.00 ± 3.02 (10)

4.90 ± 3.03 (10)

0.0117

−0.93

8.67 ± 4.24 (36)

7.03 ± 4.49 (36)

0.0004

−0.62

9.89 ± 3.55 (9)

4.44 ± 4.22 (9)

0.0039

−1.57

Nondepressed (GDSSF-K < 5)

MoCA-K

16.82 ± 4.20 (77)

17.70 ± 5.71 (77)

0.1078

0.25

19.00 (1)

18.00 (1)

>0.9999

16.67 ± 2.73 (6)

14.67 ± 3.14 (6)

0.0313

−2.25

MMSE-DS

23.84 ± 4.29 (77)

24.18 ± 4.14 (77)

0.4868

0.11

28.00 (1)

29.00 (1)

>0.9999

21.33 ± 5.82 (6)

22.33 ± 2.88 (6)

0.8750

0.26

GDSSF-K

2.09 ± 1.36 (77)

2.05 ± 1.95 (77)

0.1828

−0.02

2.00 (1)

3.00 (1)

>0.9999

2.00 ± 0.89 (6)

1.67 ± 0.52 (6)

0.6875

−0.32

Depressed (GDSSF-K ≥ 5)

MoCA-K

17.87 ± 3.56 (222)

21.09 ± 4.24 (222)

<0.0001

1.07

18.33 ± 3.57 (9)

21.56 ± 5.85 (9)

0.0313

0.75

16.73 ± 4.66 (30)

19.30 ± 5.58 (30)

<.0001

0.98

17.11 ± 4.65 (9)

22.56 ± 4.22 (9)

0.0039

1.40

MMSE-DS

23.41 ± 3.49 (222)

26.02 ± 3.13 (222)

<0.0001

0.93

24.11 ± 2.85 (9)

26.00 ± 2.18 (9)

0.0313

0.77

22.97 ± 3.73 (30)

24.93 ± 3.85 (30)

<.0001

1.03

23.22 ± 3.42 (9)

26.44 ± 2.55 (9)

0.0156

1.24

GDSSF-K

9.24 ± 3.05 (222)

6.72 ± 3.83 (222)

<0.0001

−0.84

8.67 ± 2.29 (9)

5.11 ± 3.14 (9)

0.0078

−1.11

10.00 ± 3.24 (30)

8.10 ± 4.15 (30)

0.0006

−0.68

9.89 ± 3.55 (9)

4.44 ± 4.22 (9)

0.0039

−1.57